Senior Data Scientist, Proteomics

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

FL94 is a NewCo pioneering the discovery of protein editors as a new category of medicines.  To reach this goal we are creating the industry’s first generative covalent chemistry platform foundationed on merging AI with a massively scalable proprietary data generation paradigm that will programmably create actionable covalent small molecules targeted to any protein class.  Both small molecule modulation of canonical function (using mono-valent editors) and novel induced proximity-driven functions (using bi-valent editors) are in scope to treat diseases spread within the full human proteome, not just the currently ligandable.

Position Summary:

FL94 is seeking a motivated Senior Data Scientist to join the proteomics team. In this role you will be a principal stakeholder in establishing and streamlining the data strategy for the chemical proteomics focused protein editing platform. The ideal candidate is an enthusiastic collaborator who will work with colleagues from all departments to design and deploy data science solutions, thus driving the FL94 drug discovery pipeline.

Key Responsibilities:

• Develop and implement robust computational and statistical methods to analyze large scale (chemo)proteomics datasets.
• Develop and streamline custom, automated data processing pipelines and strategies for rapid data analysis and dissemination.
• Create intuitive data visualization tools and dashboards for interdisciplinary team use.
• Perform unit tests and conduct reviews with other team members to ensure code is robust and efficient.
• Work closely with the machine learning team to triage targets and ensure data quality to facilitate generative design of protein editing chemistries.
• Ensure rapid and accurate turnaround of data to drive achievement of key project goals.
• Collaborate with crossfunctional teams, including proteomics, biology, chemistry and machine learning departments to enhance the integration and utility of proteomics data.
• Integrate proteomics data with other -omics datasets to better understand disease biology and drive drug discovery programs.

The successful candidate will have all the following skills necessary to perform in a fast-paced, purposeful, highly integrated, and pioneering environment:

• Ph.D. in bioinformatics, computational biology, statistics, or other related fields with 3+ years of experience in an industry setting
• High level of proficiency in programming languages such as Python and/or R.
• Familiarity with various proteomics data acquisition strategies (TMT, DIA and label free).
• A strong grasp of proteomics processing pipelines, such as Proteome Discoverer, FragPipe, DIA-NN, Skyline, or MaxQuant.
• Previous experience analyzing chemical proteomics data is preferred.
• Strong command of SQL database management and operations is preferred.

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com

 Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies*: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect there to.*