Sr Program Manager, Compliance & Salesforce Governance

Location: USA - South San Francisco, CA

Department: General & Administration

Sr Program Manager, Compliance & Salesforce Governance

(Hybrid in South San Francisco)

Summary

Twist Bioscience is seeking a Senior Program Manager to lead IT Governance, Risk & Compliance (GRC), SOX control framework design, and technology governance across the enterprise Salesforce ecosystem. This senior individual-contributor role will own the design, implementation, assessment, and continuous improvement of the IT SOX control framework, ensuring technology risks impacting financial reporting are effectively identified, governed, and mitigated.

The role will serve as a strategic GRC partner to Internal Audit, Internal Controls, Finance, Information Security, Technology, business process owners, and external auditors like E&Y.

Core Responsibilities

• Own the design, implementation, and continuous improvement of the Salesforce IT SOX/GRC control framework.
• Translate SOX and technology risks into effective ITGCs, application controls, policies, and governance standards.
• Embed controls into solution design, implementations, integrations, and technology changes.
• Lead risk and control assessments, testing, deficiency remediation, and continuous monitoring.
• Govern Segregation of Duties (SoD), privileged access, and access reviews.
• Partner with Technology, Finance, Information Security, Internal Controls, and business teams to strengthen the control environment.
• Lead SOX audit coordination, including walkthroughs, evidence, testing, and remediation with Internal Audit and external auditors.
• Establish end-to-end technology governance across Salesforce and financially relevant integrations, including release governance and control automation.
• The role will coordinate and govern releases but will not develop, independently approve, and deploy the same production change, preserving appropriate segregation of duties.

Key Qualifications

• 5+ years of experience in Program Management
• Proven experience designing, implementing, and improving IT control frameworks within a publicly traded company.
• Experience translating business and technology risks into effective, sustainable controls, policies, and governance standards.
• Experience leading control assessments, walkthroughs, testing, deficiency evaluation, and remediation with Internal Audit and external auditors.
• Strong understanding of access, Segregation of Duties (SoD), privileged access, change management, and technology governance controls.
• Experience designing controls across enterprise applications, integrations, and financially significant systems.
• Strong ability to influence cross-functional stakeholders and drive governance initiatives without direct management authority.

Preferred Qualifications

• Experience leading enterprise GRC or IT SOX control framework transformation and continuous improvement initiatives.
• Experience with Salesforce and/or other enterprise CRM and ERP platforms.
• Experience with GRC platforms, continuous controls monitoring, and control automation.
• Salesforce Sales Cloud, Service Cloud, and Data Cloud.

Success in This Role

Success will be measured by establishing a scalable, sustainable, and risk-based IT GRC and SOX control framework that:

• Withstands internal and external audit scrutiny and maintains strong audit readiness.
• Identifies and addresses SOX and financial-reporting risks early, particularly through technology and solution design.
• Maintains effective control design, ownership, Segregation of Duties, and privileged-access governance.
• Provides clear, consistent control documentation, evidence, monitoring, and accountability.
• Drives timely and sustainable remediation of control gaps and deficiencies.
• Enables efficient, consistent governance across Salesforce, integrations, and downstream financially relevant systems while supporting business growth and technology innovation.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.