Co-op: Quality Control
Location: Cambridge, MA
Department: Analytical Development
Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.
Fall 2026 Co-op: Quality Control
Co-Op Assignment Overview
Prime Medicine is seeking a co-op for the Fall 2026 semester with experience in biological and/or chemical techniques to join the Analytical Development and Quality Control (QC) team. The candidate will gain hands-on experience supporting analytical testing for gene therapy programs, including prime editing components, drug substances, and drug products.
This co-op will learn cutting-edge analytical technologies, develop an understanding of scientific and regulatory requirements for phase-appropriate analytical testing, and contribute to solving complex technical challenges related to prime editing programs. This is a unique opportunity to directly support the advancement of transformative genetic medicines toward the clinic.
We are looking for curious problem solvers who enjoy working collaboratively, thrive in a fast-paced environment, and are passionate about advancing genetic editing technologies to improve human health.
Primary Responsibilities
- Support product development sample analyses, in-process, release, and stability testing for LNP-based drug products, prime editing component RNAs, and cell-based drug products.
- Execute and support cell-based analytical activities.
- Perform cell-based potency, viability, conduct cell counting.
- Assist with optimization, troubleshooting, validation, and qualification of analytical methods.
- Participate in stability and reference standard programs including protocol/report preparation, data compilation, trending, and analysis.
- Assist with sample management and chain-of-custody documentation.
- Conduct clean room laboratory environmental monitoring for GMP manufacturing suites.
- Document and communicate experimental data in electronic notebooks and quality systems in accordance with cGMP requirements.
- Collaborate cross-functionally with Analytical Development, Manufacturing, MSAT, and Program Teams to support product and method development and qualification/validation.
- Contribute to laboratory functionality, safety compliance, and QC process optimization.
- Identify opportunities for assay optimization, workflow improvements, and automation.
- Demonstrate flexibility in supporting new projects, troubleshooting activities, and evolving program priorities.
Qualifications
- Currently enrolled in a B.S. or M.S. program in Biology, Biochemistry, Biotechnology, Bioengineering, Microbiology, Chemistry, Chemical Engineering, Pharmacology, or related field.
- Completion of foundational biology, biochemistry, microbiology, chemistry, and/or cell biology coursework with laboratory components.
- Experience with aseptic technique and basic cell culture is highly desirable, or liquid nanoparticle technology.
- Ability to work both independently and collaboratively.
- Self-motivated, detail-oriented, and organized with strong problem-solving skills.
- Excellent verbal and written communication skills.
- Eagerness to learn GLP/GMP practices and analytical methodologies.
- Comfortable engaging in cross-functional teamwork.
- Ability to manage multiple projects in a dynamic, fast-paced environment.
Preferred Qualifications
- Understanding of fundamental principles behind biological and chemical analytical techniques such as UV-Vis, HPLC/UPLC, LC-MS, PCR/qPCR/ddPCR, and potency assays.
- Hands-on experience with biological or chemical analytical techniques including sample preparation, dilution, extraction, and analysis.
- Experience with cell-based assays (e.g., viability assays, flow cytometry, functional assays).
- Familiarity with cell therapy or gene editing technologies.
- Prior internship or co-op experience in the biotechnology industry.
What We Offer
- A cutting-edge, collaborative team committed to mentorship and professional development.
- Exposure to gene and cell therapy analytical strategies in a GMP-regulated environment.
- Participation in seminars with industry experts.
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education.
Note: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
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