High-Throughput Functional Genomics (Discovery) Lead

Location: New York

Department: Research

Position Summary

We are seeking a visionary, hands-on scientific leader to drive our high-throughput functional genomics discovery platform. In this role, you will collaborate closely with experimental and computational teams across Neptune, manage and develop a high-performing group of scientists and research associates, and lead the onboarding and scale-up of next-generation single-cell screening technologies. You will serve as a technical authority in genomics technologies across the organization and play a central role in enabling large-scale screening for Neptune’s discovery engine—building a unique data moat that powers rapid and continuous target identification.

The ideal candidate brings deep expertise in advanced single-cell CRISPR screening and sequencing technologies, combined with strong people leadership, project management experience, and a demonstrated ability to deliver large-scale projects under tight timelines. This role requires a highly collaborative, team-oriented mindset with a focus on generating high-quality results at speed.

About You

• Scientific expert and team leader: You bring deep expertise in advanced single-cell and CRISPR screening technologies and have a strong track record of building and mentoring high-performing scientific teams through clear goals, execution, and guidance.
• Systems thinker and process optimizer: You think naturally at scale - building  efficient workflows, and enabling large-volume research while balancing scientific rigor with operational demands.
• Results-driven: You thrive in fast-paced environments with tight deadlines, excel at prioritization, and consistently deliver complex projects on time within high-throughput settings..
• Collaborative Team-player: You enjoy leading and mentoring a team of research scientists and associates, and you excel at working across experimental, computational, and operational teams to achieve shared goals. 
• Adaptable learner: You stay current with emerging genomics technologies, apply sound judgment when adopting innovations, and can pivot strategies effectively to meet evolving organizational needs

Key Responsibilities

• Act as a key individual contributor in a highly collaborative team, providing hands-on expertise in the lab to de-risk new technologies and scale up robust workflows for our high-throughput single-cell screening platform
• Plan, manage, and execute a large-scale target discovery initiative focused on high-throughput single-cell CRISPR screening in vitro (2D and 3D) and in vivo
• Manage multiple complex projects simultaneously, ensuring timely execution under tight deadlines
• Lead, mentor, and manage a dedicated team of scientists and senior research associates, fostering a culture of innovation, collaboration, and scientific rigor
• Spearhead the identification, evaluation, and implementation of cutting-edge technologies to enhance the speed, scale, and quality of our target discovery campaigns
• Drive the design, execution, and optimization of sophisticated screening assays and technology development projects that directly impact program objectives
• Develop and champion the strategic vision for technology innovation within our target discovery platform, staying current with rapidly evolving scientific fields and identifying, evaluating, and implementing new methodologies
• Oversee experimental design, protocol development, and resource allocation across the target discovery platform to ensure project milestones and scientific objectives are met
• Effectively analyze and present data, clearly communicating research plans, progress, and timelines to the team
• Present scientific findings, project updates, and strategic proposals to internal and external stakeholders, contributing to publications and intellectual property filings
• Collaborate closely with the CompBio team to build robust screening workflows, and maintain detailed, well-organized, and timely documentation of experiments and data

Qualification and Education Requirements

You must have:

• PhD, MD, or MD/PhD in genomics, biomedical engineering, molecular biology, or a related field, with training in high-throughput single-cell methodologies and next-generation sequencing
• 3–5+ years of relevant experience in academia, biotechnology, or the pharmaceutical industry
• Prior experience in a leadership or mentorship role, with a demonstrated ability to manage and develop Ph.D. level scientists effectively
• Proven record of delivering large, complex projects under tight deadlines in fast-paced, high-throughput environments
• Demonstrated hands-on expertise and a strong, proven track record in genome engineering, CRISPR screening design, and high-throughput single-cell functional genomics
• Deep expertise in molecular biology, biomedical engineering, high-content CRISPR screening, and single-cell genomics, supported by several years of academic or industry experience
• Extensive knowledge of NGS library preparation workflows and the computational aspects of multi-omic profiling
• Experience with a wide range of biological systems, including mammalian cell culture, primary cells, and complex cellular models (e.g., 3D organoid cultures and mouse models) relevant to biologics discovery
• Experience with—or strong enthusiasm for—working at the interface of biology and data science, with the ability to collaborate effectively with AI/ML and computational scientists
• Strong problem-solving abilities and an aptitude for innovation
• Ability to adapt quickly to shifting priorities while delivering high-quality, detail-oriented results on time
• A high degree of teamwork and a collaborative mindset, along with the ability to work independently

Additional preferred experience includes:

• Industry experience post-PhD is desirable
• Experience implementing process improvements and automation in production settings
• Willingness to quickly discover and learn new methods and approaches
• High motivation, with a strong work ethic and dedication to generating impact.
• Experience with computational data handling, processing, and analysis
• Long-term personal vision with defined career goals.
• Outstanding written and verbal communication skills