Real job — pulled straight from Mayo Clinic’s careers page · Verified October 3, 2026 · No reposts.
Job description
Mayo Clinic is hiring a Senior Information Security Engineer — a full-time, based in Rochester, MN role ($134k–$195k). Apply directly on Mayo Clinic's careers page below.
SR Information Security Engineer - IS-Mod
Location: Rochester, MN, US
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
Responsibilities
The Senior Information Security Engineer is a senior-level technical position responsible for leading complex security engineering initiatives and providing advanced expertise across multiple information security domains. The position operates with significant autonomy, serves as a technical authority, and is accountable for designing, implementing, and optimizing security solutions that address enterprise risk, regulatory requirements, and business objectives.
The ideal candidate serves as a technical architect for privileged access management, leading the design and implementation of PAM solutions across the enterprise and setting the technical direction others build against. This includes demonstrated experience administering and supporting CyberArk/Idira solutions in a large, complex environment, including Privilege Cloud, secrets management (Conjur, Secrets Hub, and Central Credential Provider), and Endpoint Privilege Manager, as well as hands-on work onboarding privileged accounts, designing safe and platform structures, and implementing credential rotation, session isolation, and session recording through CPM and PSM. Familiarity with the Microsoft administrative tier model and why Tier 0 and Tier 1 access warrants the strongest protections is expected. Experience integrating privileged access controls with identity governance, MFA, and SIEM platforms is strongly preferred, as is proficiency with scripting and automation (PowerShell, Python, and REST APIs) to streamline onboarding, reporting, and day-to-day operations.
Equally important is the ability to partner effectively with infrastructure, application, and clinical technology teams to reduce privileged access risk without disrupting patient care operations. Candidates should be able to explain privileged access requirements and associated risk clearly to both technical staff and leadership, and should bring experience supporting audit and regulatory requirements in healthcare or another highly regulated industry.
This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.
Qualifications
Bachelor’s degree in applicable field plus five (5) years of relevant experience. Pertinent fields of study and experience include, but are not limited to, information security, computer science, information systems, engineering, or a related field.
Master’s degree in applicable field plus four (4) years of relevant experience preferred. Pertinent fields of study and experience include, but are not limited to, information security, computer science, information systems, engineering, or a related field.
One or more of the following certifications (or equivalent) are required at time of hire: CISSP, CISM, GSEC, OSCP.
Exemption Status
Exempt
Compensation Detail
$134,347 - $194,750 / year;
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
Monday - Friday Days This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs in Rochester MN.
Weekend Schedule
Weekends if on call projects dictate Participates in 24/7 on call rotation with on call occurring approx. every 6 weeks.
International Assignment
No
Site Description
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'. Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
Recruiter
Shelly Weir
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Frequently asked questions
What is the salary for Senior Information Security Engineer at Mayo Clinic?
The estimated salary range for Senior Information Security Engineer at Mayo Clinic is $134,000 - $195,000 USD per year.
What skills are required for Senior Information Security Engineer at Mayo Clinic?
The required skills for Senior Information Security Engineer at Mayo Clinic include: PowerShell, Python, REST, SIEM, CISSP, CISM.
What is the seniority level for Senior Information Security Engineer at Mayo Clinic?
Senior Information Security Engineer at Mayo Clinic is a Senior level position.
How do I apply for Senior Information Security Engineer at Mayo Clinic?
You can view the full description and apply for Senior Information Security Engineer at Mayo Clinic on EchoJobs: https://echojobs.io/job/mayo-clinic-sr-information-security-engineer-is-mod-dza7n.