Real job — pulled straight from Mayo Clinic’s careers page · Verified October 3, 2026 · No reposts.
Job description
Mayo Clinic is hiring a Senior Information Security Engineer — a full-time, based in Rochester, MN role ($134k–$195k). Apply directly on Mayo Clinic's careers page below.
SR Information Security Engineer - IS-Mod - 80651
Location: Rochester, MN, US
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
Responsibilities
The Senior Information Security Engineer is a senior-level technical position responsible for leading complex security engineering initiatives and providing advanced expertise across multiple information security domains. The position operates with significant autonomy, serves as a technical authority, and is accountable for designing, implementing, and optimizing security solutions that address enterprise risk, regulatory requirements, and business objectives.
Depending on the area of focus, the Senior Information Security Engineer may lead Secure Software Development Lifecycle (SSDLC) initiatives focused on enabling security across software development and delivery pipelines or advancing security practices for agentic and AI-assisted software development. Examples of such activities include the following:
- Serves as a technical subject matter expert, collaborating across Information Security and IT to translate security requirements into practical and scalable solutions. Provide adoption guidance for developers.
- Design and maintain representative development environments and CI/CD pipelines to evaluate, validate, and demonstrate application security tools and controls.
- Design and maintain representative agentic development workflows to test and validate security controls.
- Research emerging agentic and AI-assisted development practices and associated security risks and controls.
- Evaluate security technologies and capabilities for risks introduced by agentic and AI-assisted software development.
Qualifications
Bachelor’s degree in applicable field plus five (5) years of relevant experience. Pertinent fields of study and experience include, but are not limited to, information security, computer science, information systems, engineering, or a related field.
Master’s degree in applicable field plus four (4) years of relevant experience preferred. Pertinent fields of study and experience include, but are not limited to, information security, computer science, information systems, engineering, or a related field.
One or more of the following certifications (or equivalent) are required at time of hire: CISSP, CISM, GSEC, OSCP.
Preferred Qualifications
- Strong software, systems, platform, or security engineering experience supporting modern application development and delivery environments.
- Strong understanding of SSDLC and application security practices, with experience translating security requirements into technical solutions and guidance.
- Experience with CI/CD pipelines, build processes, cloud or container technologies, and application security controls such as SAST, SCA, and software supply chain security.
- Experience with AI-assisted and agentic software development technologies and workflows, including associated application security risks and controls.
- Strong technical leadership, communication, and collaboration skills across security and technology teams.
This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.
Exemption Status
Exempt
Compensation Detail
$134,347 - $194,750 / year
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
Monday - Friday Days This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.
Weekend Schedule
Limited nights and weekend based on work load.
International Assignment
No
Site Description
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'. Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
Recruiter
Shelly Weir
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Frequently asked questions
What is the salary for Senior Information Security Engineer at Mayo Clinic?
The estimated salary range for Senior Information Security Engineer at Mayo Clinic is $134,000 - $195,000 USD per year.
What skills are required for Senior Information Security Engineer at Mayo Clinic?
The required skills for Senior Information Security Engineer at Mayo Clinic include: CI/CD, CISSP, CISM.
What is the seniority level for Senior Information Security Engineer at Mayo Clinic?
Senior Information Security Engineer at Mayo Clinic is a Senior level position.
How do I apply for Senior Information Security Engineer at Mayo Clinic?
You can view the full description and apply for Senior Information Security Engineer at Mayo Clinic on EchoJobs: https://echojobs.io/job/mayo-clinic-sr-information-security-engineer-is-mod-80651-2t0nd.