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Principal Software Engineer

Illumina

On-site
Singapore
Full-time
Principal
Manager
12+ yrs
Salary not listedPosted 1h ago

Real job — pulled straight from Illumina’s careers page · Verified August 18, 2026 · No reposts.

Job description

Illumina is hiring a Principal Software Engineer — a full-time, based in Singapore role. Apply directly on Illumina's careers page below.

Principal Software Engineer 1

Location: Singapore - Woodlands - NorthCoast

Time Type: Full time

Job Description

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Position Summary:

Technical architect for Illumina Data Platform ensuring technological evolution in alignment with the Illumina Software Architecture

Position Responsibilities:

  • Own the architecture responsibility to transform the existing Data Platform to the next generation and evolving it to be an essential integrated part of our Informatics product offering.

  • Provide leadership for the architecture of a new Data Platform for genomics

  • Participate and contribute to the global SW architecture team for cross product/platform solutions and integrations

  • Contribute and assist in providing architectural oversight to ensure delivery of new informatics platform and software products of the highest quality according to committed timelines through effective resource planning and allocation

  • Champion the adoption of AI assisted Development

  • Works collaboratively within the global teams across Illumina to ensure consistent and seamless user experience across the portfolio

  • Creates connections and works collaboratively across functions within R&D (Engineering, Software Instrument & Informatics), across geographies (US and Belgium) and functions to ensure products meet customer needs and function exquisitely at a whole system level

  • Envisions, champions, and implements program best practices following Illumina’s Product Development Process

  • Contribute and assist the Singapore SW Development organisation to build a center of excellence with a top-notch Software team by ensuring technical relevance and raising technical competencies of the team.

  • Participates in product strategy and planning efforts with senior leadership across Product

  • Participates in the Software leadership team

Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs.

Position Requirements:

  • 12+ years of hands on experience in developing SW architecture for large complex solutions, preferably in the life sciences and software industry.

  • Experience using AI tools to develop software and architecture

  • Demonstrated experience in taking conceptual research through development to a viable product for commercialization

  • Excellent communication skills, including verbal, written and presentation

  • Excellent technical leadership skills -including the ability to set architectural vision; plan and execute activities to achieve the vision

  • Strong analytical skills and ability to tie detailed analysis to larger strategy

  • Experience developing products in an FDA regulated environment would be highly desirable

  • Strong leadership skills and experience managing senior level engineering professionals

All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional task and responsibilities

Preferred Experience/Education/Skills:

  • Typically requires a minimum of 15 years of related experience with a Bachelor’s degree; or 12 years and a Master’s degree; or a PhD with 8 years’ experience; or equivalent experience.

  • Experience delivering programs on cloud hyperscalers (AWS, GCP, Azure) and/or life sciences software 

  • Experience as a software architect for a minimum of XX years

  • Experience working in an AI-native software development environment required

  • Experience with data pipeline and workflow orchestration systems a plus 

  • Experience with population-scale genomics, biobank programs, or other large scientific data platforms a plus

  • Background in genomics, bioinformatics, or computational biology a plus

  • Partner- or customer-facing delivery experience on a complex technical engagement 

  • Experience working with life sciences quality management systems a plus


We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.

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Frequently asked questions

What skills are required for Principal Software Engineer at Illumina?

The required skills for Principal Software Engineer at Illumina include: AI, Cloud Computing, AWS, GCP, Azure.

What is the seniority level for Principal Software Engineer at Illumina?

Principal Software Engineer at Illumina is a Principal / Manager level position.

How do I apply for Principal Software Engineer at Illumina?

You can view the full description and apply for Principal Software Engineer at Illumina on EchoJobs: https://echojobs.io/job/illumina-principal-software-engineer-1-3f7ax.