Principal Research Associate, NGS

Key Responsibilities:

• Independently lead and develop new projects, experiments, and scientific processes to support the characterization and development of new assays and modalities. 
• Actively undertake technology development and assay optimization efforts to enhance research capabilities.
• Keep up with technical advances in cell and molecular biology, innovating on assays and research projects.
• Design, execute, and analyze experiments involving mammalian cell culture, molecular biology techniques, and gene therapy applications.
• Perform nucleic acids extraction, quantitation, gel electrophoresis, PCRs, qPCRs, and other molecular biology techniques.
• Develop and optimize NGS pipelines, including Illumina-based DNA and RNA library construction, QC using TapeStation and fragment analyzer, and running MiSeq/NextSeq.
• Independently execute protocols, troubleshoot assays, and conduct literature searches for technology selection and onboarding.
• Maintain meticulous records of experimental procedures and results, including electronic lab notebook maintenance.
• Collaborate effectively in a cross-functional, multi-disciplinary environment to achieve research goals.

Basic Qualifications:

• B.S. with 6+ years or M.S. with 3+ years of relevant experience in cell and molecular biology, biotechnology, or a related field.
• Extensive experience in mammalian cell culture, including primary and cancer cell lines (e.g., U2OS, HEK293).
• Expertise in a broad range of molecular biology techniques and assay optimization.
• Proficiency in nucleic acids extraction, quantitation, gel electrophoresis, PCRs, qPCRs, and related techniques.
• Experience with NGS pipelines, including Illumina-based DNA and RNA library construction, QC, and sequencing.
• Strong attention to detail in executing experiments and maintaining records.
• Ability to work independently and collaboratively in a team-oriented environment.

Preferred Qualifications:

• Experience with mouse/human primary hepatocytes, iPSCs, and 3D cell culture.
• Familiarity with long-read sequencing technologies.
• Experience with liquid handling and automated NGS pipelines.
• Understanding of genome engineering technologies and their applications.

What we offer:

• A highly competitive salary, a meaningful equity ownership stake in Deep Genomics, and exceptional opportunities for learning and growth.
• Company paid benefits.
• You’ll also be joining a bright, collegial, highly-motivated group working at the intersection of two of the most exciting areas of science and technology: AI and biotechnology.