Staff Software Engineer, Science

The Team

CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. 

Our vision is to build the future of science by advancing biomedical research and leveraging advances in AI. Over the next 10 years, we’re working to understand the mysteries of the cell, which we believe will lead to discoveries that will change medicine in the decades that follow. We’ll use emerging tools, methods, and models to make new discoveries and spur the translation of basic science into groundbreaking treatments and therapies.

CZI’s work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science.

The Opportunity

The Data Engineering team manages and processes scientific datasets specifically designed to enable biological modeling. It is responsible for data validation, wrangling, testing, storage, and retrieval. We handle over 89 million unique cells worth of single cell transcriptomic data, over 15 thousand cryoET tomograms that  are in imaging datasets as large as 20TB and counting, and will be expanding to support larger scale and additional imaging, sequencing, and literature modalities. Our resources provide access to open source data that is structured and used  by tens of thousands of scientists each month to quickly query and form hypotheses on understanding how genetic variants in cells impact disease risk, define drug toxicities, and eventually discover better therapies.

As a staff software engineer on the Data Engineering team, you will design and implement all the data needs for our platforms, CELLxGENE Discover, CryoET, as well as the new platform we are building that has a focus on data for AI and the virtual cell, in order to enable scientists to further interrogate our very large and growing corpus of data without any need to download the data itself or have any computational expertise. You will work on a collaborative, multidisciplinary team to develop solutions for our scientist users to accelerate their workflows and accelerate the pace of scientific discovery. You will be responsible for setting the direction of how our teams ingest, transform, validate, process, store, monitor, and utilize petabytes of data for ease of use, search and modeling. You will also be responsible for upscaling the engineers around you and influencing the proper technical best practices and data design for efficient and effective delivery.

No prior biology experience is required for this role. You will have the opportunity to pair with Computational Biologists to develop solutions for our users and be able to learn about biology from experts on our team.

Our tech stack: Python, Terraform, AWS infrastructure, TileDB.

What You'll Do

• Develop end-to-end, robust data pipeline architectures that seamlessly integrate data ingestion, preprocessing, feature engineering, model training, and deployment.
• Implement scalable data warehousing solutions to handle massive volumes of single-cell transcriptomics data and imaging data.
• Ensure data security and compliance with industry standards and regulations.

• Implement optimization strategies such as data partitioning, indexing, and compression to enhance query performance and reduce computational costs.

• Create user-friendly APIs to enable researchers and scientists to easily access and explore the curated data.

• Develop scalable, maintainable, and testable software systems and participate in team conversations and efforts on engineering excellence.
• Collaborate with product managers, computational biologists, UX designers, and other software engineers to deliver constant incremental value for scientists without compromising on software quality.
• Have opportunities to learn about scientific data and technologies, though no prior experience is required!

What You'll Bring

• 8+ years of relevant software experience
• Strong fundamentals in systems design, data structures, algorithms, and object oriented programming principles.
• Past experience with data processing and orchestration pipelines, such as Argo Workflows, Databricks
• Solid experience with object oriented programming languages and scripting languages, such as Java, C++, Python, Golang, etc.
• Past experience with big data.
• Some experience with infrastructure and automation tools, such as Kubernetes, Terraform, AWS.
• Excellent written and verbal communication skills.
• Enthusiasm to ramp up on technologies and learn a new science domain.
• Experience working in a multidisciplinary environment (engineering, product, design).
• Desirable but not required: experience with scientific computing libraries, such as NumPy and SciPy.

Compensation

The Redwood City, CA base pay range for this role is $214,000 - $321,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Pay ranges outside Redwood City are adjusted based on cost of labor in each respective geographical market. Your recruiter can share more about the specific pay range for your location during the hiring process.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• CZI provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs.
• CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving to the Bay Area
• And more!

Commitment to Diversity

We believe that the strongest teams and best thinking are defined by the diversity of voices at the table. We are committed to fair treatment and equal access to opportunity for all CZI team members and to maintaining a workplace where everyone feels welcomed, respected, supported, and valued. Learn about our diversity, equity, and inclusion efforts. 

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

Explore our work modes, benefits, and interview process at www.chanzuckerberg.com/careers.

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