Senior/Principal Scientist, Chemoproteomics

Location: South San Francisco, CA

Department: DISCOVERY TECHNOLOGIES

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. 

Position Description: 

Calico is seeking an experienced Scientist to join the mass spectrometry proteomics group. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. The work will primarily involve chemoproteomics techniques using mass spectrometry to support drug discovery. You will work with a large number of samples for drug discovery, optimize, develop and apply proteomics methods, and be responsible for a range of chemoproteomics workflows and projects to advance drug discovery programs.  

Responsibilities: 

• Prepare samples from many sources, including proteins, cells, tissues and biofluids
• Optimize, develop and apply proteomics and chemoproteomics sample preparation methods 
• Maintain and troubleshoot instruments including HPLCs, mass spectrometers and other bioanalytical equipment 
• Analyze data to share with collaborators 
• Present results at internal lab meetings and company-wide meetings

Position Requirements: 

• PhD in Analytical Chemistry, Chemistry, Chemical Biology, Biochemistry, Chemical Engineering or related field 
• Minimum 5 years technical experience post-PhD with experience in the biopharma industry 
• Experience in method development for HPLC and/or mass spectrometers  
• Experience in maintaining and troubleshooting HPLCs and mass spectrometers 
• Experience in sample preparation for proteomics and chemoproteomics
• Experience in multiplexed proteomics (e.g. TMT) 
• Experience in enrichment and analysis of PTMs 
• Experience with activity based proteome profiling and cysteine enrichment workflows (e.g. CysPAT, DBIA) 
• Experience in proteomics data analysis and programming (Python, R, MATLAB)
• Detail-oriented and organized 
• Strong teamwork and communication skills 
• A track record of strong research/drug discovery productivity 
• Self-motivated with a “can-do” attitude is required for success 
• Flexible, able to respond quickly to shifting priorities and able to multitask
• Must be willing to work onsite five days per week 

Nice to Have: 

• Experience with Thermo mass spectrometers (Lumos/Eclipse/Astral)
• Experience with Agilent mass spectrometers and Rapid Fire 
• Experience with high throughput proteomics and automation (e.g. Hamilton Vantage)
• Experience with Click chemistry 
• Experience with Top down proteomics

The estimated base salary range for this role is $166,000 - $207,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.