Scientist/Senior Scientist for Pharmacology

Location: Waltham, Massachusetts, United States

Department: 0600 Pharmacology

Workplace: on_site

Employment Type: full

Description

Biocytogen Boston Corp is seeking a highly motivated and versatile Pharmacology Scientist to support both in vivo and in vitro preclinical research services in the fields of immunology, immuno-oncology, metabolic disease and neurology. This role is ideal for candidates with broad expertise in pharmacological studies, disease model development, and cell-based assays, who are passionate about evaluating novel therapeutic agents for clients.

The successful candidate will be a critical member of our fast-paced and expanding CRO team, actively engaging in both hands-on experimental work and strategic project management to support biotech and pharmaceutical partners

Key Responsibilities

In Vivo Pharmacology

• Design and develop animal models, execute in vivo experiments to evaluate the biological efficacy of novel therapeutic agents.
• Independently lead in vivo service projects and preclinical studies, acting as Project Manager or Study Director.
• Perform animal handling, tumor inoculation, drug administration via multiple routes, blood and tissue collection, tumor measurements, and PK/PD studies.
• Design and execute internal model-building projects and characterize various humanized mouse models.
• Provide troubleshooting support and technical guidance to junior associates.
• Collaborate closely with the BD/Sales team for client project planning and technical discussions.
• Present project results to clients and internal stakeholders; prepare scientific reports and summaries.
• Mentor and facilitate the growth of junior research associates.

In Vitro and Ex Vivo Pharmacology

• Independently develop, validate, and perform a broad range of in vitro and ex vivo assays including:
• Immune cell profiling from blood and tissues.
• Functional assays using primary cells (T cells, NK cells, macrophages).
• Cytokine profiling, cytotoxicity, and apoptosis assays.
• Develop new assay technologies by researching scientific literature and adapting methodologies from collaborations and other internal teams.
• Perform flow cytometry (FACS), ELISA, Western blot, qRT-PCR, and multiplex cytokine analyses.
• Contribute to the design and support of in vivo pharmacology studies from an in vitro perspective.
• Present research findings at internal meetings and contribute to external scientific discussions.

Requirements

• PhD in pharmacology, immunology, cancer biology, or related biomedical field.
• Extensive hands-on experience in animal models and preclinical in vivo pharmacology.
• Proven skills in cell-based immunological assays including T cell activation, NK cell-mediated cytotoxicity, and macrophage functional assays.
• Proficiency in PK/PD model establishment and analysis.
• Expertise in flow cytometry, cytokine profiling (ELISA, qRT-PCR, multiplex assays), and immune cell isolation from tissues.
• Experience with surgical procedures in rodents is highly desirable
• Cross-functional knowledge across therapeutic areas is a plus.
• Strong communication, organizational, and team collaboration skills with the ability to prioritize in a fast-paced environment.
• Demonstrated ability to independently manage projects and work with cross-functional teams.

Benefits

• Medical Insurance
• Dental Insurance
• Vision Insurance
• Health Reimbursement Accounts
• Life and AD&D Insurance
• Short & Long Term Disability Insurance
• 401K with Company Match
• Paid Time Off
• Paid Sick Days & Holidays

BIOCYTOGEN is an Equal Opportunity Employer. Employment opportunities at BIOCYTOGEN BOSTON CORP are based upon one’s qualifications and capabilities to perform the essential functions of a particular job. All employment opportunities are provided without regard to race, color religion, sex, national origin, ancestry, age, sexual orientation, gender identity and expression, veteran status, military status, disability, mental illness, genetic information, or any other characteristic protected by law. This Equal Employment Opportunity policy governs all aspects of employment, including, but not limited to, recruitment, hiring, selection, job assignment, promotions, transfers, compensation, discipline, termination, layoff, access to benefits and training, and all other conditions and privileges of employment.