Graduate Intern - Antibody Repertoire Bioinformatics
Location: Minneapolis, MN
Remote Type: Hybrid
Time Type: Full time
Job Description
By joining Bio-Techne, you’ll join a company with a powerful and positive purpose of enabling cutting-edge research in Life Sciences and Clinical Diagnostics. Bio-Techne, and all of its brands, provides tools for researchers to further treat and prevent disease worldwide.
Pay Range:
$16.80 - $23.10Project Summary:
We are seeking a motivated graduate intern to develop and implement a bioinformatics pipeline for identifying paired heavy and light chain antibody sequences from single-cell RNA sequencing data. The intern will build a customized immunoglobulin gene reference data set, run and optimize a V(D)J informatics pipeline, and perform clonotype analysis and preliminary repertoire characterization. This project supports ongoing antibody development in our lab, with opportunities to contribute to novel repertoire discovery.
Pay Rate: $24.00 an hour
Key Responsibilities:
- Curate and assemble V(D)J germline gene reference databases suitable for input to V(D)J informatics pipelines.
- Build and validate custom reference files.
- Process raw single-cell RNA-seq FASTQ datasets.
- Troubleshoot pipeline runs and optimizes parameters.
- Analyze output clonotype and chain pairing data; generate summary reports and visualizations.
- Document protocols, workflows, and develop reusable scripts for the project.
- Collaborate with lab members to interpret biological relevance of antibody repertoires.
Required Qualifications:
- Current graduate student in bioinformatics, computational biology, molecular biology, or related field.
- Familiarity with Linux command line and scripting (bash, Python, or R).
- Basic knowledge of immunology and antibody biology preferred.
- Experience with next-generation sequencing data processing.
- Strong critical thinking skills and ability to work independently.
- Excellent communication and documentation skills.
Preferred Qualifications:
- Experience with single-cell RNA-seq or immune repertoire analysis.
- Knowledge of workflows such as 10x Genomics data formats and Cell Ranger software.
- Familiarity with immunoglobulin gene annotation tools (IgBlast, MiXCR, TRUST4).
Program Requirements:
- Must be a currently enrolled student pursuing a graduate-level degree in a field relevant to the internship
- Must be able to work full-time during the duration of the internship program
Why Join Bio-Techne:
We offer competitive insurance benefits starting on day one: medical, dental, vision, life, short-term disability, long-term disability, pet, and legal and ID shield.
We invest in our employees’ financial futures through 401k plans, an employee stock purchase plan (ESPP), Health Saving Account (HSA), Flexible Spending Account (FSA), and Dependent Care FSA.
We empower our employees develop their careers through mentorship, promotional opportunities, training and development, tuition reimbursement, internship programs, and more.
We offer employee resource groups, volunteer paid time off, employee events, and charity drives to build a culture of caring and belonging.
We offer an accrued leave policy with paid holidays, paid time off, and paid parental leave.
We foster a culture of empowerment and innovation, where employees feel valued and encouraged to bring their new ideas to the table.
Bio-Techne is an E-Verify Employer in the United States.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
To protect the interests of all, Bio-Techne will not accept unsolicited resumes from any source other than a candidate application. Any unsolicited resumes sent to Bio-Techne will be considered Bio-Techne property.
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