Real job — pulled straight from BigHat Biosciences’s careers page · Verified September 6, 2026 · No reposts.
Job description
BigHat Biosciences is hiring a Machine Learning Scientist — a full-time, based in San Mateo, CA role ($150k–$200k). Apply directly on BigHat Biosciences's careers page below.
Machine Learning Scientist
Department: DS/ML (Data Science/Machine Learning)
Employment Type: Full Time
Location: San Mateo, CA, San Mateo, CA, Hybrid
Key Responsibilities
- Design and implement the next state-of-the-art generative models of antibody sequence and structure, and predictive models of antibody properties, trained on proprietary internal datasets of thousands to millions of antibodies.
- Develop multi-modality, multi-objective iterative protein sequence optimization approaches to lab-in-the-loop antibody design problems for validation and deployment in our high-throughput wet lab - at BigHat success is only declared upon synthesis of real antibodies with drug-like properties.
- Develop, refine, and deploy agentic and LLM-driven optimization methods to further automate and accelerate our design-build-test loop.
- Provide ML expertise and support for ongoing therapeutics programs, directly contributing to the development of new drugs.
- Collaborate with our engineering team to ensure maximal efficiency in the automated deployment of our latest models and methods.
- Work closely with an interdisciplinary team of drug developers, wet lab scientists, automation specialists, data scientists, etc. - every therapeutics program at BigHat is heavily interdisciplinary.
Skills Knowledge and Expertise
- PhD in ML/CS/EE or relevant scientific discipline, hands on experience developing and applying novel ML methods and a strong quantitative background.
- Strong competency in Python, familiarity with PyTorch (even without LLMs!) and experience with modern software engineering best practices, including not just agentic/LLM-assisted coding but testing, CI/CD, etc.
- Excellent communication skills, sufficient biomedical domain knowledge to interact effectively with diverse scientific teams.
- Energy and ambition - ready to dive into a fast-paced environment and execute across multiple projects.
- Familiarity with the current state-of-the-art in ML-driven protein engineering
- Nice-to-haves include experience with de novo design, NGS data, Bayesian optimization, familiarity with antibody biology and drug development, experience training and deploying models on AWS, and publications at major ML conferences.
Total Rewards
Get Machine Learning Scientist jobs like this→
New roles from thousands of companies land hourly, straight from their careers pages. Get the freshest matches by email so you never miss one.
Email me new jobsSimilar jobs
Software Engineer, Data Security (Remote)
Frequently asked questions
What is the salary for Machine Learning Scientist at BigHat Biosciences?
The estimated salary range for Machine Learning Scientist at BigHat Biosciences is $150,000 - $200,000 USD per year.
What skills are required for Machine Learning Scientist at BigHat Biosciences?
The required skills for Machine Learning Scientist at BigHat Biosciences include: Python, PyTorch, AWS, Machine Learning, Deep Learning, LLM.
What is the seniority level for Machine Learning Scientist at BigHat Biosciences?
Machine Learning Scientist at BigHat Biosciences is a Staff level position.
How do I apply for Machine Learning Scientist at BigHat Biosciences?
You can view the full description and apply for Machine Learning Scientist at BigHat Biosciences on EchoJobs: https://echojobs.io/job/bighat-biosciences-machine-learning-scientist-ds-ml-data-science-machine-learning-bzes6.