Senior Scientist – Peptide Chemistry UK - Cambridge

Job Title: Senior Scientist – Peptide Chemistry

Location: Cambridge

Salary: competitive

Introduction to role:

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases.  

Currently we are seeking a skilled and enthusiastic peptide chemist, who will be part of a chemistry team developing the next generation of peptide medicines.

As a peptide chemist, you will be responsible for the design and chemical synthesis of therapeutic peptides and reagents. We are looking for someone who has a good understanding and background in solid-phase synthesis to support delivery of our peptide portfolio. In this laboratory-based position, you will be responsible for multi-step synthesis, purification and analytical characterisation of complex peptides. You will work independently within research teams and also with internal or external stakeholders. This role requires a strong background in peptide chemistry, excellent problem-solving skills and the ability to work in a fast-paced, collaborative environment.

As part of a growing team, you will benefit from numerous personal and professional development opportunities at AstraZeneca.

Accountabilities:

• Independently plan and execute complex experimental work

• Design and synthesize peptides using solid-phase peptide synthesis (SPPS) techniques, using both automated peptide synthesisers and manual procedures

• Troubleshoot and resolve synthetic and analytical challenges

• Cleavage of peptides from resin supports, purification by preparative HPLC and analysis using mass spectrometry techniques

• Contribute to multi-disciplinary research and drug development

• Communicate results to global project teams and stakeholders

• Maintain accurate and detailed experimental records and results

• Stay current with advancements in peptide chemistry and related fields

Essential Skills/Experience:

• Postgraduate qualification (or equivalent) in Chemistry, Biochemistry or relevant subject area

• Deep understanding of chemistry and peptide chemistry

• Technical proficiency in solid-phase and/or peptide synthesis via manual syntheses or automated peptide synthesisers

• Familiarity and working knowledge of HPLC purification and mass spectrometry

• Excellent record-keeping and strong written and verbal communication skills

• Experience of working within a team environment and developing good working relationships with individuals across organisational boundaries

Desirable Skills/Experience:

• PhD (or Master’s degree with equivalent lab-based experience)

• Skills in rational/ computational design of peptides

• Previous experience within the pharmaceutical industry

• Experience of working with peptide conjugates or bioconjugation techniques

What is next?

Are you ready to make a difference? Apply today and join us in our mission to improve global public health!

We welcome your applications not later than 12th January 2025.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Are you ready to make a difference? Apply today and join us in our mission to improve global public health!

Date Posted

02-Jan-2025

Closing Date

12-Jan-2025

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.